Isochron, Lord of Combos

Meanace, First strike, Trample, Infect, Defender
This card can't be sacrificed.
When you sacrifice a permanent with mana value
8 or higher, you may have Isochron, Lord of Combinations deal 3 damage to target permanent.
{p/g} sacrifice a creature; creatures you control get a
+1/+1 counter
{p/r}{p/r}: you lose 2 life, this card loses defender.